Hani Raoul Khouzam
Pharmacological agents currently available for the treatment of primary insomnia have demonstrated limited long-term efficacy and problematic side effects. The purpose of this review is to highlight the concerns surrounding the most widely used medications that are commonly prescribed for the management of primary insomnia, and to summarize the mechanism of action and beneficial effects of the orexin receptor antagonists suvorexant, lemborexant and daridorexant as alternative therapeutic interventions for the management of primary insomnia.